Frontiers Lecture: Prof Bruce Arndtsen

MoSE 3201A
Thursday, October 10, 2019 - 11:00am to 12:00pm

New Classes of Transition Metal Catalyzed Bond Forming Reactions Powered by CO  

Abstract: Transition metal catalysis has become a powerful tool in designing new classes of bond forming reactions.  In addition, there has been growing interest in exploiting metal catalyst reactivity to mediate a series of operations, as these can potentially allow the spontaneous build-up of complex compounds in a single operation.  Our lab has been actively exploring a number of these concepts, with the general goal of designing efficient synthetic routes of products directly from feedstock reagents.  A feature of many these transformations is the use of the readily available small molecule, carbon monoxide, as a tool to drive the energy efficient formation of products that are themselves reactive (acid chlorides, 1,3-dipoles), and undergo subsequent, spontaneous transformations. This talk will describe our development of these transformations, their application to the modular generation of pharmaceutical cores, super electrophiles, new classes of polymers, or the design of alternative catalytic bond forming reactions, as well as the use of external factors such as light to drive their catalytic formation.  

References:  Kinney, R.G.; Tjutrins, J. Liu, N. J.; Arndtsen, B. A. Nature Chemistry 2018, 10, 193; Macias, M. D. L. H.; Arndtsen, B. A. J. Am. Chem. Soc. 2018, 140, 10140;  Torres, G.M.; Quesnel, J. S.; Bijou, D.; Arndtsen, B. A.  J. Am. Chem. Soc. 2016, 138, 7315; Leitch, D.C.; Kayser, L. V; Han, Z. Y. Siamaki, A. R.; Keyzer, E. N.;  Arndtsen, B. A. Nature Communications, 2015, 6, 7411.

Contact Information: 
Host:  Prof Joseph P. Sadighi
Map of Georgia Tech

School of Chemistry & Biochemistry

901 Atlantic Drive Atlanta, GA 30332-0400

(404) 894-4002 (phone) | (404) 894-7452 (fax)