Rafael Montenegro-Burke

MoSE 3201A
Tuesday, February 18, 2020 - 4:00pm to 5:00pm

Rethinking metabolite identification and discovery within biological context


Mass spectrometry-based untargeted metabolomics is an emerging field focused on the profiling
of small molecules, collectively known as the “metabolome”, in biological fluids and tissues. Over
the past 15 years, innovative analytical and bioinformatics strategies have been developed, making
it possible to prioritize dysregulated metabolites for activity screening and determine their
biological function in specific phenotypes. However, many metabolites are yet to be identified, let
alone reported, characterized or incorporated into libraries. These metabolites, commonly referred
to as the “dark metabolome” are found dysregulated in different phenotypes and their identification
represents a considerable challenge for the basic understanding of many biological processes. This
seminar will focus on current progress in biological applications, bioinformatics developments and
metabolite identification that advance our understanding of biological processes.

Contact Information: 
Prof. M.G. Finn
Map of Georgia Tech

School of Chemistry & Biochemistry

901 Atlantic Drive Atlanta, GA 30332-0400

(404) 894-4002 (phone) | (404) 894-7452 (fax)