Chemistry Games at Science at Hand

For the first time this year, graduate students and postdocs from the Center for Chemical Evolution brought something new to the table: game based demonstrations of processes essential to origins chemistry.

Metabolic Profiles Distinguish Early Stage Ovarian Cancer with Unprecedented Accuracy

A new study has produced a set of biomarkers that may enable development of an accurate ovarian cancer screening test.

Second Annual Graduate-Faculty Research Symposium

Students and faculty enjoy a weekend retreat to collaborate and connect with their peers and faculty in a fun and informal environment.

Fall 2015 Safety Awards Announced!

Cynthia Martin, Dylan Christiansen and Johanna Smeekens receive the VWR Safety award for their remarkable efforts to keep GT-CHEM safe!

Glass shop featured in "Hidden Georgia Tech"

Across the Georgia Tech campus, hidden spaces and forgotten places await rediscovery.

Georgia Tech announces a new graduate program in quantitative biosciences

The Quantitative Biosciences Graduate Program (QBioS) is now accepting applications from students who want to enter a rapidly emerging field working at the leading edge of research that spans biological scales from molecules to organisms to ecosystems.

Seminars & Events

Meeting - Tuesday, December 1, 2015 - 11:00am - MoSE 3201A
Dr. Alina Schimpf - Massachusetts Institute of Technology
Special Seminar - Tuesday, December 1, 2015 - 4:00pm - MoSE 3201A
Dr. Emily Tsui - University of Washington
Special Seminar - Thursday, December 3, 2015 - 4:00pm - MoSE 3201A
Dr. Stavroula Hatzios - Harvard University Medical School
Special Seminar - Monday, December 7, 2015 - 4:00pm - MoSE 3201A

Featured Research

Article Title
Research Authors
Weixuan Chen, Johanna M. Smeekens, Ronghu Wu.
Chemical Science (2015), Vol. 6(8), 4681-4689
Miscellaneous Details
This work is supported by the National Science Foundation (CAREER Award, CHE-1454501)

Glycoproteins on the cell surface are ubiquitous and essential for cells to interact with the extracellular matrix, communicate with other cells, and respond to environmental cues. Although surface sialoglycoproteins can dramatically impact cell properties and represent different cellular statuses, global and site-specific analysis of sialoglycoproteins only on the cell surface is extraordinarily challenging. An effective method integrating metabolic labeling, copper-free click chemistry and mass spectrometry-based proteomics was developed to globally and site-specifically analyze surface N-sialoglycoproteins. Surface sialoglycoproteins metabolically labeled with a functional group were specifically tagged through copper-free click chemistry, which is ideal because it is quick, specific and occurs under physiological conditions. Sequentially tagged sialoglycoproteins were enriched for site-specific identification by mass spectrometry. Systematic and quantitative analysis of the surface N-sialoglycoproteins in cancer cells with distinctive invasiveness demonstrated many N-sialoglycoproteins up-regulated in invasive cells, the majority of which contained cell adhesion-related domains. This method is very effective to globally and site-specifically analyze N-sialoglycoproteins on the cell surface, and will have extensive applications in the biological and biomedical research communities. Site-specific information regarding surface sialoglycoproteins can serve as biomarkers for disease detection, targets for vaccine development and drug treatment.  

Map of Georgia Tech

School of Chemistry & Biochemistry

901 Atlantic Drive Atlanta, GA 30332-0400

(404) 894-4002 (phone) | (404) 894-7452 (fax)