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Working with Pharmaceutical Industry Professionals Before Graduation

GlaxoSmithKline co-op program gives Ph.D. chemistry student Cynthia Martin real-life training in drug discovery.

GT Students Learn Beaujolais Traditions

Forty-six Georgia Tech undergraduates recently had the opportunity to visit the Beaujolais region as part of the fifth annual faculty-led study abroad program in Lyon in France.

Heme, a Poisonous Nutrient, Tracked by ‘Green Lantern’ Sensor

Reddi lab features in Research Horizons for recent PNAS paper

Meet Casey Bethel, Georgia's 2017 Teacher of the Year

College of Sciences basks in the reflected glow of a GIFTed science teacher

New award recognizes Wendy Kelly, Joseph Sadghi, and William Baron

Congratulations to Professors Wendy Kelly, Joseph Sadighi and William Baron as the inaugural recipients of the Vasser Woolley Award for Excellence in Instruction in the School of Chemistry and Biochemistry.

Kristy S. Syhapanha Puts a Foot in the Door of Her Dream Career

Kristy Southysa Syhapanha never thought of studying at Georgia Tech. She didn’t think she would qualify, so she didn’t bother – at first.

Missing Links Brewed in Primordial Puddles?

Researchers have achieved a significant advancement toward unlocking a longstanding evolutionary mystery -- how components of RNA and DNA formed from chemicals present on early Earth before life existed.

Welcome to Dr. Gutekunst

The School of Chemistry and Biochemistry is pleased to welcome Dr. Will R. Gutekunst, who will join the faculty on July 1, 2016 as an Assistant Professor.

Welcome to Dr. La Pierre

The School of Chemistry and Biochemistry is pleased to welcome Dr. Henry S. La Pierre, who will join the faculty on July 1, 2016 as an Assistant Professor with a courtesy appointment in the George W. Woodruff School of Mechanical Engineering and the Nuclear and Radiological Engineering and Medical Physics Program.

Seminars & Events

Prof. Dr. Daniel B. Werz - Technische Universitaet Braunschweig
Special Seminar - Monday, August 1, 2016 - 4:00pm - MoSE 3201A
Meeting - Tuesday, August 16, 2016 - 11:00am - MoSE 3201A
Meeting - Tuesday, September 20, 2016 - 11:00am - MoSE 3201A
Meeting - Tuesday, October 18, 2016 - 11:00am - MoSE 3201A

Featured Research

Article Title
Research Authors
Araujo, RN; Franco, PF; Rodrigues, H; Santos, LCB; McKay, CS; Sanhueza, CA; Brito, CRN; Azevedo, MA; Venuto, AP; Cowan, PJ; Almeida, IC; Finn, MG; Marques, AF.
Citation
International Journal for Parasitology (2016), Vol. 46(3), 213-210
Miscellaneous Details
Conselho Nacional de Desenvolvimento Científico e Tecnológico, Brazil, Fundação de Amparo a Pesquisa de Minas Gerais (FAPEMIG), Brazil, and NIH, USA. ICA is partially supported by NIH/NIMHD, Special Visiting Researcher of the Science Without Borders Prog.

The anaphylaxis response is frequently associated with food allergies, representing a significant public health hazard. Recently, exposure to tick bites and production of specific IgE against alpha-galactosyl (alpha-Gal)-containing epitopes has been correlated to red meat allergy. However, this association and the source of terminal, non-reducing alpha-Gal-containing epitopes have not previously been established in Brazil. Here, we employed the alpha-1,3-galactosyltransferase knockout mouse (alpha 1,3-GalT-KO) model and bacteriophage Q beta-virus like particles (Q beta-VLPs) displaying Gal alpha 1,3Gal beta 1,4GlcNAc (Gal alpha 3LN) epitopes to investigate the presence of alpha-Gal-containing epitopes in the saliva of Amblyomma sculptum, a species of the Amblyomma cajennense complex, which represents the main tick that infests humans in Brazil. We confirmed that the alpha-1,3-galactosyltransferase knockout animals produce significant levels of anti-alpha-Gal antibodies against the Gal alpha 1,3Gal beta 1,4GlcNAc epitopes displayed on Q beta-virus like particles. The injection of A. sculptum saliva or exposure to feeding ticks was also found to induce both IgG and IgE anti-alpha-Gal antibodies in alpha-1,3-galactosyltransferase knockout mice, thus indicating the presence of alpha-Gal containing epitopes in the tick saliva. The presence of alpha-Gal-containing epitopes was confirmed by ELISA and immunoblotting following removal of terminal alpha-Gal epitopes by alpha-galactosidase treatment. These results suggest for the first known time that bites from the A. sculptum tick may be associated with the unknown etiology of allergic reactions to red meat in Brazil. (C) 2016 Australian Society for Parasitology Inc. Published by Elsevier Ltd. All rights reserved.  

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