Chemistry Lab Safety Video - Choose-Your-Own-Adventure Style

Are those shoes you're wearing lab safe? What do you do when you splash acid in your eye? Georgia Tech's School of Chemistry and Biochemistry has developed this video, in the choose-your-own-adventure style to help you learn how to get through the lab in one piece. Click your answer (sorry, doesn't work on mobiles) when the time comes and see if you're right.

New Prof Amit Reddi is a Metal Maniac

Amit Reddi is a new assistant professor in the School of Chemistry and Biochemistry with a specialty in bio-inorganic chemistry. We sat down with Reddi to find out more about him and his work.

Grad Student Troy Alexander Makes Discovery in Amazon, Stumps Scientists

Georgia Tech Chemistry and Biochemistry grad student Troy Alexander found a hitherto unexplained web-tower-thing growing in the Amazon. Scientists are stumped as to what it is. See the story in Wired.

Grad Students and the Quest for the Origins of Life

Want to learn how life began? You can do that. Chemistry and Biochemistry graduate student Eric Parker tells how.

Seminars & Events

Special Seminar - Monday, April 21, 2014 - 4:00pm - MoSE G011
Asst. Prof. Steven E. Wheeler - Texas A&M University
Physical Division Seminar - Tuesday, April 22, 2014 - 11:00am - MoSE 3201A
Prof. Stephen Lippard - Massachusetts Institute of Technology
Colloquium - Tuesday, April 22, 2014 - 4:00pm - MoSE G011
Prof. Eric Betzig - Janelia Farm Research Campus, Howard Hughes Medical Institute
Peter B. Sherry Memorial Lecture - Thursday, April 24, 2014 - 4:00pm - MoSE G011

Featured Research

Article Title
Research Authors
Michael H. Smith and L. Andrew Lyon.
Citation
Accounts of Chemical Research (2012), Vol. 45, 985-993
Miscellaneous Details
National Institutes of Health

The application of RNA interference to treat disease is an important yet challenging concept in modern medicine. In particular, small interfering RNA (siRNA) have shown tremendous promise in the treatment of cancer. However, siRNA show poor pharmacological properties, which presents a major hurdle for effective disease treatment especially through intravenous delivery routes. In response to these shortcomings, a variety of nanoparticle carriers have emerged, which are designed to encapsulate, protect, and transport siRNA into diseased cells. To be effective as carrier vehicles, nanoparticles must overcome a series of biological hurdles throughout the course of delivery. As a result, one promising approach to siRNA carriers is dynamic, versatile nanoparticles that can perform several in vivo functions.

Over the last several years, our research group has investigated hydrogel nanoparticles (nanogels) as candidate delivery vehicles for therapeutics, including siRNA. Throughout the course of our research, we have developed higher order architectures composed entirely of hydrogel components, where several different hydrogel chemistries may be isolated in unique compartments of a single construct. In this Account, we summarize a subset of our experiences in the design and application of nanogels in the context of drug delivery, summarizing the relevant characteristics for these materials as delivery vehicles for siRNA.

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