Menu
Close

Professor Pamela Peralta-Yahya selected 2016 Kavli Fellow

Professor Pamela Peralta-Yahya was selected as a 2016 Kavli Fellow by the National Academy of Sciences.

Prof. Reddi wins NSF CAREER award

Amit Reddi has won a five-year grant will support research on metals in the body from the National Science Foundation.

Josh Allen, BS '08, makes Forbes 30 under 30 list!

Josh Allen (BS Chemistry, 2008) has been named one of 2016’s Forbes 30 under 30 for healthcare. Josh parlayed his experience at GT into a PhD in Biochemistry and Molecular Biophysics from the University of Pennsylvania where he discovered ONC201 as a novel first-in-class anticancer agent. He is currently the Vice President of Research and Development at Oncoceutics.

Peralta-Yahya group makes cover of ACS Synthetic Biology

Research group uses G-protein coupled receptors (GPCRs) known to bind medium-chain fatty acids in mammalian cells to rapidly construct chemical sensors in yeast.

Siyuan Zhang Wins MRS Gold Graduate Student Award

Graduate student Siyuan Zhang made a big splash at the recent national meeting of the Materials Research Society.

Seminars & Events

Meeting - Tuesday, February 16, 2016 - 11:00am - MoSE 3201A
Prof. Amber Krummel - Colorado State University
Analytical Division Seminar - Tuesday, February 16, 2016 - 4:00pm - MoSE 3201A
Prof. Karen L. Wooley - Texas A&M University
Colloquium - Thursday, February 18, 2016 - 4:00pm - MoSE G011
Dr. Janez Plavec - Slovenian NMR center, National Institute of Chemistry, and University of Ljubljana
Biochemistry Division Seminar - Tuesday, February 23, 2016 - 11:00am - IBB Suddath Room

Featured Research

Article Title
Research Authors
Weixuan Chen, Johanna M. Smeekens and Ronghu Wu.
Citation
Chemical Science (2016), Vol. 7, 1393-1400
Miscellaneous Details
This work is supported by the National Science Foundation (CAREER Award, CHE-1454501)

Protein dynamics are essential in regulating nearly every cellular event, and aberrant proteostasis is the source of many diseases. It is extraordinarily difficult to globally study protein dynamics and accurately measure their half-lives. Here we have developed a chemical proteomics method integrating protein labeling, click chemistry and multiplexed proteomics, which overcomes current challenges with existing methods. Labeling with both azidohomoalanine (AHA) and heavy lysine allows us to selectively enrich newly synthesized proteins, clearly distinguish them from existing proteins, and reduce the impact of heavy amino acid recycling. Moreover, multiplexed proteomics enables us to quantify proteins at multiple time points simultaneously, thus increasing the accuracy of measuring protein abundance changes and their half-lives. Systematic investigation of newly synthesized protein dynamics will provide insight into proteostasis and the molecular mechanisms of disease.

Map of Georgia Tech

School of Chemistry & Biochemistry

901 Atlantic Drive Atlanta, GA 30332-0400

(404) 894-4002 (phone) | (404) 894-7452 (fax)