Comprehensively mapping the genetic basis of human disease across diverse individuals is a long-standing goal for the field of human genetics. A key limitation in efforts to build this catalogue has been the historic under-representation of large subsets of individuals in biomedical research including individuals from diverse ancestries, individuals with disabilities and individuals from disadvantaged backgrounds. The All of Us Research Program, which includes School of Biological Sciences Professor I. King Jordan, is a longitudinal cohort study aiming to enroll a diverse group of at least one million individuals across the USA, advancing the promise of genomic medicine for all.