Fourier transform mass spectrometry (FTMS) provides the highest levels of analytical performance for mass accuracy and resolving power.  Modern analysis requirements for high throughput studies present a confounding challenge to provide these benefits with increased acquisition speed.  These needs lie in juxtaposition to traditional Fourier methods where the observation of extended time domain signals leads to a linear enhancement in these metrics.  The presented work focuses on FTMS imaging technology developments and will describe two approaches to meet this challenge - the introduction of external data acquisition systems and the modification of analyzer cells to enable alternative detection schemes.  Ongoing applications to model organism systems for environmental exposure related to infectious disease, ionizing radiation, and emerging pollutants will be highlighted.