It has been almost a quarter-century since M.G. Finn, K. Barry Sharpless, and Hartmuth C. Kolb published the paper that some refer to as the click manifesto. In it, the researchers presented a vision for synthetic chemistry that prioritizes quick and easy access to functional molecules. Today, click reactions can be found nearly everywhere organic bonds come in handy. They even garnered Sharpless, Carolyn Bertozzi, and Morten Meldal the Nobel Prize in Chemistry in 2022. The authors of the manifesto envisioned a future in which the grand challenge of synthetic chemistry would be figuring out not how to make a molecule but what molecule to make and what it would be good for, says M.G. Finn, professor and chair in the School of Chemistry and Biochemistry. The key to achieving that future: reactions of exceptional speed, ease, selectivity, and reliability.