When Marielle Frooman joined the McShan Lab, she brought a strong passion for chemistry, but no lab experience. Today, the fourth-year Georgia Tech biochemistry student is the first co-author of a groundbreaking malaria study published in Scientific Reports, a Nature Portfolio journal. Through extensive experimentation coupled with computer modeling, Frooman led a team of undergraduate and graduate researchers that uncovered eight peptides that can help the immune system recognize and fight the malaria parasite. 

“Malaria kills over 500,000 annually with the mortality rate substantially higher in Africa,” says Frooman. “Our research explores how specific peptides bind to proteins that trigger immune responses.”

Frooman originally hoped the research would help her learn how to think like a scientist and gain basic lab knowledge.

She gained those skills and more, quickly becoming recognized as an exceptional researcher.

“Marielle is one of the most passionate and talented undergraduate researchers I have ever worked with,” says Andrew McShan, McShan Lab principal investigator and associate professor in the School of Chemistry and Biochemistry. “She is also a caring mentor and motivated future leader who wants to change the world. Her malaria research has the potential to provide real therapeutic outcomes, including better designs for vaccines and immunotherapy.” 

From curiosity to contribution

Frooman’s journey into undergraduate research began with persistence. After a year and a half of searching for lab opportunities, she attended a School of Chemistry and Biochemistry research showcase. She approached several graduate students and professors with no success, until she met McShan.

“Our first meeting was so relaxed and friendly that I didn’t even realize Professor McShan was the principal investigator,” admits Frooman. “That’s how it all started.”

Once she officially joined the lab, Frooman contributed to every stage of the research, including designing experiments, performing computational and wet lab work, analyzing data, and writing and presenting the paper.

Lessons in resilience

The team faced several challenges.

“The research was delayed by failure after failure,” says Frooman. “But each setback taught us something valuable.”

The team’s biggest challenge involved trying to grow crystals of the peptide/HLA (protein) complexes to determine how they fit together. They spent two years attempting various methods, but nothing worked.

Guided by McShan, Frooman and the team then came up with the idea of using computational modeling to enable a deeper understanding of how the peptides and proteins interact at both biophysical and structural levels.

“Utilizing the computational modeling enabled us to see the best bindings and turned into a game-changing insight for our research, potentially leading to the design of more effective malaria treatments and vaccines,” explains Frooman.

She is quick to credit Georgia Tech and McShan for providing her with such a valuable learning experience.

“At many universities, undergraduates rarely do meaningful research, but at Tech, it’s a priority,” explains Frooman. “I’m extremely grateful for the opportunity to grow in such a supportive environment, and to learn from mentors like Professor McShan who lead by example and make time for every student.”

Her advice to other undergraduates entering research?

“Embrace your failures. They make the successes even more rewarding,” shares Frooman.

Outside the lab

On campus, Frooman is president of the Student Affiliates of the American Chemical Society and Cleanup Crew at GT, a member of Alpha Phi International Fraternity, and a campus tour guide who serves on their executive board. 

She especially loves being a tour guide as it allows her to share her love of Georgia Tech and its people:

“Everyone is unapologetically themselves and fully invested in their major or interests. As someone who loves chemistry, I enjoy being surrounded by people who are just as dedicated to their passions.”

Frooman is a recipient of the Chance Family Scholarship, presented to two School of Chemistry and Biochemistry upperclassmen, recognizing their academic excellence, research contributions, and potential for career success in the field.

Recently, she shifted her research focus to organic synthetic chemistry and now works in the Gutekunst Lab. Her career goals include earning a Ph.D. in Chemistry with an emphasis on natural product synthesis, the lab-based creation of complex chemical compounds found in nature.

“I’ve seen what university labs can do,” says Frooman. “I hope to one day lead my own lab, advancing impactful research and mentoring the next generation of scientists.”